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NNMT enzyme inhibition occurs within 24 hours of subcutaneous dosing based on pharmacokinetic modelling, but downstream metabolic effects NAD+ elevation, changes in fat oxidation markers typically require 24 weeks of consistent dosing to manifest in measurable endpoints

10.1093/ecco-jcc/jjaa182

Lie, J.-A

Because proper assembly and function of the electron transport chain (ETC) are essential for mitochondrial respiration and limiting oxidant stress (Vercellino and Sazanov 2022), we next assessed ETC protein expression

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