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Molecular biology and biochemistry of pyruvate dehydrogenase complexes

4.1 Binge drinking model The acute alcohol intragastric model can simulate the liver damage caused by binge ethanol in people with no drinking history

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Furthermore, increased copper levels can increase reactive oxygen species (ROS) production and activate the NF-B signalling pathway, exacerbating inflammatory changes within the vascular wall and promoting atherosclerosis (25)