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The anti-inflammatory pathways are primarily mediated by the farnesoid X receptor (FXR) and the Takeda G protein-coupled receptor 5 (TGR5) 147

[20] [33] Oral hygiene practices can address metallic taste or altered oral sensations: Brush teeth and tongue regularly Use alcohol-free mouthwash Chew sugar-free gum or mints Rinse mouth with baking soda solution (1/4 teaspoon in 1 cup water) Taste changes often improve over weeks to months as the body adjusts to therapy, though individual experiences vary

These are well tolerated by most people with little to no pain, apart from the sensation of a sharp scratch

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In the sections below, we explore the key topics that were defined, such as the targets, the bulk procurement that will be conducted by utilities, and the funding incentives meant to provide the near-term missing money. We also review what was not (or could not be) resolved through the Order