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These advantages include enhanced physical stability, safeguarding susceptible pharmaceuticals against degradation, regulated release mechanisms, and exceptional tolerability 15,16

Clinical trials of RT combined with STING agonists Currently, common STING agonists in the clinic are synthetic cyclic dinucleotide (CDN) and its analogs, chemical drugs such as platinum and paclitaxel, metal ions such as manganese/zinc/iron/calcium, small-molecule inhibitors such as PAPR, small-molecule drugs such as SR-717, and small interfering RNAs (siRNAs) [10, 11]