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As late diagnosis is one of the most important barriers accounting for poor outcome and high mortality, our findings pave the path for an early diagnosis method

After the experimental objectives were met, the animals were treated in a scientific and humane manner to minimize their panic and suffering, and euthanasia was performed gently and quickly

Enrichment analyses using the STRING software (version 11) [24] also revealed an overrepresentation of GO (gene ontology) biological processes consistent with key events in EMT (in bold in Table 4)