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Neoadjuvant checkpoint blockade for cancer immunotherapy

score 3: more than 50% irregular vascularization: increased number of capillaries, groups of thick-walled blood vessels irregularly arranged in the hypercellular tendon, and a nodular proliferation of blood vessels that can also be vertically directed in relation to their counterpart fibers

Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease

It is worth noting that the anticancer and immunomodulatory role of bilirubin in nanomedicines was overlooked in some of the above experiments, which focused on its high photothermal conversion efficiency as a photosensitizer on tumors, without noting that the anticancer role of bilirubin/biliverdin as a ROS scavenger in its own right should not be underestimated