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Incretin-based pharmacotherapy now offers a medical alternative, resulting in a 15 to 20% body weight loss close to that achieved with bariatric surgery and providing considerable cardiovascular benefit

Mulla, M.H

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Mechanisms of resistance to, and toxicities resulting from, IGF-1R-targeted drugs are well-catalogued, and there is general appreciation of the fact that a lack of biomarker-based patient stratification was a limitation of previous clinical trials

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