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thaliana , six isoforms of MDHAR are present among which two are peroxisomal, two are cytosolic and one is dually targeted chloroplastic/mitochondrial isoform (Lisenbee et al., 2005) (Table 2)

10.1080/07853890.2025.2583330 84 LiZ.YanJ.LiX.ChenH.LinC.ZhangY.et al (2025)

In addition, the lack of B12 also results in reduced production of melatonin, contributing to poor gut health - often seen in CFS and also to poor sleep patterns, also characteristic of CFS

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