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Specifically, expression of the gene ICOS was significantly negatively correlated with E2F6 expression, whereas U87 cell growth was reduced upon E2F6 knockout through short hairpin RNA (shRNA) [139]

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All animal experimental protocols were approved by the Animal Ethics Committee, the Second Affiliated Hospital, School of Medicine, Zhejiang University (Approval number: 2023084)

For context on how injectable versus oral delivery compares across peptide and antioxidant compounds, this deep dive on BPC-157 orals versus injectables will give you the framework for thinking about these tradeoffs correctly