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This work demonstrates that SLC7A11-high cancer cells are vulnerable to disulfide stress under glucose starvation, laying the groundwork for the subsequent discovery of disulfidptosis

For examples, reaction-paired metabolites such as glutamate and -ketoglutarate, -ketoglutarate and cis -aconitate in TCA cycle, had isotopologue similarity scores of 0.81 and 0.96, respectively (Fig

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Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway

The kidneys of STZ-treated rats showed reduced expression of GPX4, DHODH, GSH and SOD, increased expression of TFR1 and FTH, and higher levels of iron and MDA