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When AGEs bind to RAGE, they trigger: Cytokine and growth factor release (e.g., TGF- and VEGF), leading to basement membrane thickening and diabetic retinopathy

Mitochondrial microheteroplasmy and a theory of aging and age-related disease

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As shown in Figures 1A,E and Supplementary Figure S1A, atorvastatin and lovastatin reduced cell viability with increasing concentrations of statins in HCM, C2C12 and HUVEC, while rosuvastatin and pravastatin did not (Figures 1A,E and Supplementary Figure S1A)

Because of the redox activity of the labile iron pool, it is thought to contribute to oxidative stress during iron overload (Piloni et al., 2016[345])