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Description

Arq Bras Cardiol 117:715725

During perimenopause, estradiol levels drop and estrone becomes the main form of estrogen

Moreover, a previous study revealed that yohimbine administrated at a dose of 5 mg caused a reduction of total food intake and intraperitoneal adipose tissue accumulation [19]

Thus, based on our data, we believe that for accurate determination of a new drugs DILI risk, including its placement on the hepatotoxicity spectrum, we absolutely need comprehensive assessment under both acute and chronic treatment conditions