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A few commenters stated that hospitals that contract with outside vendors or consultants to update their MRFs on an annual basis, do so at a cost of $10,000 to $30,000 per hospital and those without vendor support report needing 5 to 30 full-time-equivalents (FTEs) to update their MRFs on an annual basis

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The most important factor for any research protocol is consistency, so administering it at the same time each day is recommended

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Others are immune modulators, with peptides known to move macrophages from an inflammatory state to a repair state, reducing local cytokine production