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PMID: 33989570

Moreover, an enriched subgroup analysis of the URICOI-ICTUS trial revealed that UA treatment was safe, well-tolerated, and provided substantial benefits of UA in terms of the primary outcome(modified Rankin Scale score at day 90)

The program has helped shepherd over 400 therapies for rare conditions through FDA approval

Studies have shown that celastrol mitigates diabetic nephropathy by reducing renal tissue damage through the MAPK/NF-B and the PI3K/AKT pathways in diabetic rats [19,20,21]