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Approximately 40% of individuals with FHI do not have an identifiable mutation in any of the genes known to be associated with FHI

This supports the fact that higher enzyme expression level may lead to higher LC 50 values

J Trace Elem Med Biol: Organ Soc Miner Trace Elem (GMS) 28:492494

Follicular regulatory helper T cells play a rather ambiguous role in regulating the humoral immune response

Conclusion and perspective Research on lactate metabolism and lactate-derived lactylation, as core drivers of cancer initiation and progression, is gradually changing our traditional perception of lactate as a metabolic waste product. This review systematically examines the basic mechanisms of lactate metabolism, its abnormal manifestations in tumor cells, and the multiple roles of lactate in the TME