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7.2.3 Translational gap in pre-treatment strategies Pre-treatment strategies significantly enhance MSC homing and therapeutic efficacy in rodent models, yet in vivo validation in dogs and cats remains largely unexplored

In addition, because of different drug bioavailability and absorption, SIBO has conflicting effects on intestinal symptoms of PD with different pharmacological interventions (Gibson and Barrett, 2019

Because first year height velocity data suggests that the impact of rhIGF-1 among SPIGFD patients is less pronounced than rhGH for GH-deficiency (rhIGF-1: 6.9 [6.5, 7.2] cm/year [n = 144] vs rhGH: 8.67 [7.5, 9.9] cm/year [n = 465]) [14, 60], some HCPs may not perceive rhIGF-1 as beneficial enough for SPIGFD

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