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These include: Paraesthesia (pins and needles) in hands and feet Peripheral neuropathy with numbness or altered sensation Difficulty walking or balance problems (ataxia) Memory problems and cognitive difficulties Mood changes, including depression or irritability In severe cases, confusion or dementia-like symptoms Other manifestations may include: Loss of appetite and unintentional weight loss Constipation Visual disturbances (rare, but can occur with optic neuropathy) Important: The neurological complications of B12 deficiency can progress even in the absence of anaemia, making early detection crucial

This is because B12 is absorbed in the latter part of the small intestine, but the process requires hydrochloric acid from the stomach

Research models have demonstrated glutathiones involvement in maintaining mitochondrial integrity and supporting cellular recovery following oxidative or metabolic stress, highlighting its importance in studies focused on brain health and longevity

Optimal levels also support healthy synthesis of neuronal myelin

2025, Dec, 22;20(1):126