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It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile

This information is invaluable for your healthcare provider in determining whether symptoms are genuinely related to B12 supplementation or reflect an independent condition requiring separate investigation

Factors such as the underlying cause of your deficiency, your age, overall health, and your medical history all play a role in determining the best treatment plan for you

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