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The documented considerations include mild water retention (a class effect of raising GH), injection-site reactions, occasional headache or lightheadedness, and most importantly for long-term thinking IGF-1 and sustained-GH-elevation considerations, which are why cycling with breaks is favored over indefinite use

The Mayo Clinic also emphasizes practical steps for day-to-day relief

Functions of the Lyn tyrosine kinase in health and disease