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2) or other base analogs of uridine and cytidine residues can reduce innate immune recognition while making ASOs more resistant to nucleases

As we age, levels of glutathione the bodys master antioxidant decline

Bempedoic acid, on the other hand, was able to pass the rules of Lipinski, Ghose, and Egan Muegge without violation but could not completely pass the Veber rule with a violation (Table 5)