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In -synuclein-induced PD mouse model, Zhang and collaborators showed that the administration of caffeic acid prevents the neurodegeneration of dopaminergic neurons in SN and improves behavioral abnormalities by stimulating autophagy through the JNK/BcL2 pathway (Zhang et al., 2019)

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In animal studies, long-term administration of Epitalon has been associated with a significant increase in maximum lifespan, a reduction in chronic age-related conditions, and improved physical and cognitive function in older subjects

Inhibitory effect of astragalus polysaccharide on premetastatic niche of lung cancer through the S1PR1-STAT3 signaling pathway