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Studies have shown that klotho begins to decline in very early stages of CKD (Wang et al., 2021), and the TGF- signaling plays a crucial role in down-regulating klotho in CKD (Zhou et al., 2013)

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Structurally, the riboregulation of SHMT1 involves RNA acting as an allosteric switch by competing with folate [31]

revealed that ITGB2-AS1 inhibits p53-mediated ferroptosis by stimulating the FOSL2/NAMPT axis, which promotes cisplatin resistance in NSCLC cells

Stearns V, Beebe KL, Iyengar M, Dube E