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Is IL-6 a key cytokine target for therapy in COVID-19

Thus, these trials have not been addressed in the present manuscript

In a rat model of adjuvant-induced arthritis, the combination of metformin (200 mg/kg/day) and omega-3 (300 mg/kg/day) showed efficacy comparable to methotrexate (2 mg/kg/week) in ameliorating disease activity, with significant reductions in arthritic scores, paw swelling, and serum TNF- and IL-1 after 4 weeks (252)

However, in the context of the interaction of tamoxifen and oxidative damage, the effect of oxidative stress on tamoxifen resistance must also be highlighted

By maintaining telomere length, Epithalon may delay cellular senescence and support genomic stability in aging cells