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Collectively, these findings indicate that non-selective or excessive chelation of brain iron may disrupt physiological metallostasis, emphasizing the need for precisely titrated, brain-targeted anti-ferroptotic interventions with balanced efficacytoxicity profiles. Beyond traditional chelators, several natural compounds have also shown potential in regulating iron transport proteins

Depletion of vitamin C and vitamin E increase atherosclerosis in Apoe -/- mice (371)

Favero G, Moretti E, Bonomini F, Reiter RJ, Rodella LF, Rezzani R

Uncontrolled production of ROS during influenza virus infection can induce cell injury 74

Consult your healthcare provider before starting any supplement, especially if pregnant, nursing, taking medications, or managing a health condition.