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Nature communications, 7(1), 12948

Direct inactivation of the enzyme tyrosinase Switching off the production of the Eumelanin (gives darker complexion) Switching on the production of the Pheomelanin (gives brighter complexion) Sun exposure and oxidative stress can disrupt melanin levels, leading to an increase in Eumelanin for a darker complexion, and a decrease in Pheomelanin, resulting in a brighter tone

Li T, Song F, Zhang J et al (2020) Experimental and modeling study of proton and copper binding properties onto fulvic acid fractions using spectroscopic techniques combined with two-dimensional correlation analysis

Trichloroacetic acid (TCA) is applied to the hyperpigmented areas with a cotton swab and left for a duration depending on the patients skin type

Some natural treatments may be more effective than the conventional ones