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In the future, the blood-brain barrier (BBB) penetration issue of GLUT3 inhibitors can be overcome by developing BBB-permeable nanomedicine, and non-specific neurotoxicity can be reduced by designing tumor microenvironment-responsive (such as pH/ROS-responsive) intelligent nanomedicines

All IV therapy at OneMedicine is: Doctor-led Clinically prescribed Delivered in a regulated medical environment We may recommend baseline blood tests, including liver and kidney function, before intravenous treatment to ensure safety

Spatial transcriptomics allows high-resolution profiling of gene expression in intact cell and tissue samples (348), and has made significant advances in recent years, exerting notable influence on diverse fields, such as tissue architecture, developmental biology and disease research, particularly in cancer and neurodegenerative diseases (349)

These findings unequivocally establish that cuproptosis is distinct from other known cell death modalities, underscoring its unique mechanisms and signaling pathways

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