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A study in the Journal of Clinical Biochemistry and Nutrition found B12 benefits

23 Several centrally acting drugs, especially those that exert an effect on the dopamine system within the brain, such as antipsychotics, frequently induce secondary Parkinsonism after sustained chronic use

conducted an experimental non-targeted LC/MS metabolomics analysis in patients with IBD, extracting and analyzing serum samples from both active and non-active cases, and found that most patients showed decreased serum tryptophan and tryptophan metabolites, as well as decreased ability to utilize outstanding amino acid (113)

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