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58 In mammals, 19 members of the Wnt family have been recognized as having critical roles in regulating biological processes

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high-dose groups (up to 1,200 mg/kg) are included to assess safety

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The subjects who received amifostine maintained a normal glomerular filtration rate (GFR), a measure of kidney function, after two chemotherapy cycles, whereas a 30% reduction in GFR occurred in subjects who did not receive amifostine (Hartmann 2000)