bulletproof acetyl l carnitine L-Carnitine (ALCAR) AOR - Alcar N-Acetyl-L-Carnitine –

The microbial capacity for generating TMA appears to be important for the development of AS

Brakedal, B

Below is a hypothetical scenario to demonstrate my point: An individual suffers from long-term thiamine deficiency and has suboptimal riboflavin status Thiamine deficiency leads to lower activity of transketolase Low transketolase activity produces a lack of NADPH A lack of NADPH and a lack of FAD means that glutathione reductase is unable to efficiently recycle glutathione, which produces an imbalance between reduced/oxidized glutathione

This increases the neurotoxic metabolite QUIN while reducing the neuroprotective metabolite KYNA (Savitz, 2020)

Polymeric micelles amplify tumor oxidative stresses through combining PDT and glutathione depletion for synergistic cancer chemotherapy