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Concurrently, GA is released in response, inhibiting HMGB1 release and synergistically activating the immune microenvironment

Several studies indicate that human cells can also actively trigger ROS production at small doses, as part of signaling pathways, regulating cell survival and proliferation, as a defense mechanism against invaders (Bartosz, 2009

While prior studies mainly concentrated on the direct impact of microbial metabolites on the hosts immune cells, whether these metabolites can modulate the function of tumor cells remained unclear (260)

At the same time, an increasing body of evidence became available on the emerging network of ACKs and DAMPs/alarmins and their potential role in neuroinflammation and ischemic stroke