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doi: 10.1126/science.1223813

Additional investigations are warranted to explore the fundamental mechanisms and validate the clinical significance of capsaicin as a specific intervention for modifying DNA methylation and expression patterns of genes associated with medical conditions (25)

If the substance is no longer needed, enzymes such as diamine oxidase (DAO) in the intestine, tissue and blood, or histamine N-methyltransferase (HNMT) in the liver, bronchial mucosa and central nervous system ensure that it is broken down

The majority of QIs was reduced back to the respective parent compound (50% of AQ-QI and 80% of DEAQ-QI), presumably by the action of endogenous antioxidants and/or reductases, e.g., quinone reductases ( Figure 5B )

doi: 10.1016/j.yrtph.2015.06.016, 222