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An increase in ALT level did not occur in female rats with doses below 0.2 mmol/kg, while in male rats, the increase of ALT level could be observed with a dose of 0.1 mmol/kg of diquat

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Additionally, cholesterol metabolites, particularly oxysterols, modulate LXR and SREBP2 signaling, leading to altered lipid metabolism and metabolic reprogramming that further favors tumorigenesis [6, 11]

396 Moreover, demethylation treatment can disrupt protein methylation, leading to the accumulation of SAH while depleting cellular SAM, resulting in the inhibition of autophagy and apoptosis induced by endoplasmic reticulum stress in pancreatic cancer cells