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Quantification of the number of PLA foci per nucleus revealed that the Pol1MVI interaction takes place in about 50% nuclei (Figure 5B)

These senescent cells are not able to decidualize properly and their secretory phenotype can create a pro-inflammatory microenvironment that may interfere with endometrial receptivity (van Deursen, 2014

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Current methods rely on indirect measures such as MDA, 4-HNE, and ferritin levels, which may not be sufficient to distinguish ferroptosis from other forms of oxidative stress-driven cell death

At one, three and six-month follow-up, the rate of patients reporting minimal clinically important difference (MCID) in the IIEF-EF score was significantly higher in the treatment group, with 69% achieving MCID six months after PRP versus 27% in the placebo group (p 24 hours), shaving with clippers, and preparation with chlorhexidine-alcohol [570,571]