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Dysbiosis can affect the kynurenine pathway of tryptophan metabolism, leading to an imbalance in neuroactive metabolites that influence mood, cognition, and pain perception (He et al., 2023)

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The temperature and atmosphere mixture of 5% CO with compressed air was controlled by an Okolab Bold Line top stage incubator with an H301-K-Frame chamber (Okolab S.r.l., Italy)

in an orthotopic brain-tumor model, intrathecal administration further increased tumor uptake to 18.10 0.87%ID/g, with a tumor-to-brain ratio of 14.23 at 24 hsignificantly higher than blockade and isotype-control groups (p 100 days, and complete remissions were achieved in subcutaneous models [69, 70]

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