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10.1016/j.biomaterials.2019.119495 43 EyniH.GhorbaniS.ShiraziR.Salari AslL.P BeiranvandS.SoleimaniM

Pharmacological inhibition of USP30 activates tissue-specific mitophagy

Carvalho MMF, Reis LLT, Lopes JMM et al (2018) Aai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose

That NADH is then shuttled to the mitochondrial membrane

The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them