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Appetite suppression: The peptide helps control hunger signals, making it easier to adhere to dietary goals and manage caloric intake

Proteins typically consist of one or more long polypeptide chains with more than 50 amino acids, whereas peptides usually contain between 2 and 50 amino acids

Cagrilintide is engineered around that problem: it is a modified, lipidated peptide that acts as a dual amylin and calcitonin receptor agonist and is stable enough for once-weekly subcutaneous dosing

This causes the water in the vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure

doi:10.1056/NEJMoa2502081