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Furthermore, the released DOX impedes RNA and DNA synthesis within tumor cells, contributing to a synergistic antitumor therapy that combines CDT and CT

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Additionally, HuR deficiency resulted in pronounced mitochondrial structural abnormalities and dysfunction at 2 and 6 hours, accompanied by reduced expression of the mitochondrial fission and fusion proteins Drp1 and Mfn2, increased mitochondrial protein release, and enhanced hepatocyte death