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Studies have revealed that the hypermethylation of tumor suppressor genes such as APC, TP53, and SMAD4 in colorectal cancer is closely associated with enhanced tumor aggressiveness and metastatic potential (Nishiki et al., 2025[97]).The ERK pathway induces hypermethylation of tumor suppressor genes (such as tumor suppressor genes and differentiation-related genes) by regulating the activity of DNA methyltransferases (DNMTs)

Interestingly, these anti-inflammatory effects were not seen with acetoacetate [47]

PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex

Patients with darker skin tone are more susceptible to increased melanin production

Wang X, Su B, Perry G, Smith MA, Zhu X