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Effraimidis G, Wiersinga WM (2014) Mechanisms in endocrinology: autoimmune thyroid disease: old and new players

Fortunately, another attractive target has been identified: the thiol group in the cysteine residue forms a disulphide bridge with specific inhibitors with prolonged target engagement

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Dhonukshe-Rutten, R

To determine whether the enhanced responsiveness of IGF-1-generated signals in chondrocytes lacking the IR manifested in a greater biological response, we examined the effect of disruption of IR on chondrocyte proliferation