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European journal of pharmacology

Early-stage hydrolysis, deamidation, and oxidation do not produce visible changes

Left untreated, B12 deficiency can cause fatigue, vision problems, digestive issues, nerve damage, and mood disorders

Due to critical limitations in the treatment of AD, the bloodbrain barrier (BBB) restricts the entry of approximately 98% of the US Food and Drug Administration (FDA)-approved small-molecule drugs as well as most large-molecule therapeutics (Pardridge, 2005)