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individuals in the J haplogroup demonstrate increased susceptibility to DAMD, while those in the H haplogroup appear to be resistant to the disease [108,109,110,111]

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The scientists also noted that a number of critical issues, including pharmacokinetics and targeting, safety assessment, quantification and characterization, and manufacturing techniques, must be resolved before EXOs may be successfully converted into clinical application (Qin et al., 2025)

ONLS is axon-specific, sustaining myelin integrity and long-distance signaling in white matter tracts