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Gastrodin inhibits HO-induced ferroptosis through the antioxidative effect in rat glioma cell line C6 ( Some studies have shown that valproic acid (VPA) treatment contributes to iron metabolism in epilepsy, leading to the formation of non-transferrin-bound iron (NTBI) and an increase in oxidative stress

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Additional life years gained by treatment were evaluated by comparing restricted mean survival times (RMST) of survival models (R surv2sampleComp package) and incremental costs per life-year gained were then calculated

315 This interaction significantly reduces the availability of essential costimulatory signals for effector T cells, leading to diminished activation, proliferation, and antitumor function of these cells (Fig