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Recently, Bax and several Bcl-2 homology-3 domain (BH3)-only proteins (Bid, Puma, and Noxa) have been shown to induce a pro-oxidant state at mitochondria (1-4)

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Comparing epithelial Ido1 expression with the extensive data available for the role of Ido1 in immune cells 161 and considering the concept of competition for nutrients in the control of immune responses 164 , IECs potentially engage their metabolism to actively orchestrate mucosal immune responses