![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Electrophilic compound screening identifies GPX4-dependent](https://ars.els-cdn.com/content/image/1-s2.0-S0223523421002087-ga1.jpg)
interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Electrophilic compound screening identifies GPX4-dependent
Electrophilic compound screening identifies GPX4 dependent ferroptosis as a senescence vulnerability Nature Cell Biology Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS: Cell Chemical Biology Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines Journal of Medicinal Chemistry Discovery of novel benzylaniline derivatives containing chloroacetamide as GPX4 inhibitors with potential efficacy in triple negative breast cancer ScienceDirect Dual inhibition of carbonic anhydrase IX and glutathione peroxidase 4 as a novel strategy for ferroptosis induced tumor cell death ScienceDirect
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![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Electrophilic compound screening identifies GPX4-dependent](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41556-026-01921-z/MediaObjects/41556_2026_1921_Fig1_HTML.png)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Electrophilic compound screening identifies GPX4-dependent](https://www.cell.com/cms/10.1016/j.chembiol.2026.01.007/asset/e44364c4-658d-4195-bc7f-957b1fa35723/main.assets/fx1_lrg.jpg)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Electrophilic compound screening identifies GPX4-dependent](https://pubs.acs.org/cms/10.1021/acs.jmedchem.3c00737/asset/images/medium/jm3c00737_0012.gif)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Electrophilic compound screening identifies GPX4-dependent](https://ars.els-cdn.com/content/image/1-s2.0-S0223523425009547-ga1.jpg)
![interaction of chloroacetamide electrophiles with cellular glutathion Design, synthesis, and biological evaluation nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation Electrophilic compound screening identifies GPX4-dependent](https://ars.els-cdn.com/content/image/1-s2.0-S0223523425008724-ga1.jpg)