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Strategies include adenoviral-mediated intracavernosal gene delivery targeting eNOS, calcitonin gene-related peptide, SOD, and the RhoA/Rho kinase pathway, alongside mesenchymal stem cell-based therapies aimed at addressing age- and diabetes-related ED [122]

Neurodegeneration and AD Increased presence and activity of astrocytic Cx43 hemichannels seems to be a common feature of all major neurodegenerative pathologies, including AD, PD, HD, ALS and MS 482,483,484,485,486,487