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Key perioperative risk domains relevant to TJA and implant-based surgery potentially affected by peptide exposure are summarized in Table 4

Advanced omics technologiesincluding high-throughput genomics, proteomics, lipidomics, and metabolomicsare anticipated to enhance our understanding of the composition and functions of PDEVs, particularly by resolving vesicle heterogeneity and identifying bioactive cargo signatures

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This can contribute to dysbiosis and intestinal permeability as undigested foods are a) inflammatory to the lining of the small intestine and b) serve as food for pathogenic microbes

Vakili et al