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The anti-inflammatory effects of the MD are mediated through the gut-brain axis, with improvements in gut microbiota composition and increased SCFA concentrations being pivotal in this process (Barber et al., 2023)

Gene expression analysis shows 14 antioxidant genes upregulated and 2 pro-oxidant genes suppressed, creating comprehensive antioxidant enhancement at the transcriptional level

Acknowledgements The authors acknowledge the Researchers Supporting Project number (RSPD2025R708), King Saud University, Riyadh, Saudi Arabia, for funding this research work