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Additionally, systemic side effects associated with sustained growth hormone stimulation include symptoms such as abnormal tissue growth, joint discomfort, and potential enlargement of the heart (cardiomegaly), Roberts says (21)

Animal toxicology studies found no acute toxicity, organ damage, or reproductive toxicity across multiple routes and doses, but these studies lasted only up to 6 weeks

We followed up to ask whether the journal was aware of the March 2018 report from the university

Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats

The CCI model was established following the protocol outlined by Bennett and colleagues 19