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In that previous study (which enrolled 377 T2DM and 4741 nondiabetic controls), the prevalence of insomnia in T2DM patients was significantly higher than in nondiabetic controls, in which the prevalence of insomnia was only 12.2% [2]

To achieve the desired protective effect against nephrotoxicity, researchers should take all aspects of the relevant mechanisms into account and consider comprehensive measures or combinations of drugs

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This selectivity is crucial because many methyltransferases play essential roles in neurotransmitter metabolism, gene expression, and protein function

Risks and side effects are minimal and serious complications are rare