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Este efecto lipoltico se consigue a travs de la inhibicin de la AMPc-fosfodiesterasa

10.1093/OXFORDJOURNALS.HUMREP.A137975 47 World Health Organization (2021)

The diminished expression of this protein may have adverse effects on cardiomyocyte contraction, suggesting a potential mechanism for afatinib-induced cardiotoxicity (Wang et al., 2023)

For simplicitys sake, we refer to the GATA-binding motifs aligned in head-to-head and tail-to-tail palindromic orientations as Pal-GATA or rPal-GATA motifs, respectively

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